Tuesday, March 14, 2006

 

'Genetic network' guards against lethal DNA damage

"The discovery in yeast cells of a genetic network that guards against lethal DNA damage is a first step in the creation of a database of disease-causing combinations of mutated human genes, according to researchers at The Johns Hopkins University School of Medicine led by Jef. D. Boeke, Ph.D. In a report in the March 10 issue of Cell, the Hopkins team described a genetic network that is necessary for ensuring genomic stability in yeast. This study also identified previously unrecognized genes critical for maintaining DNA integrity and novel functions for well-known genes.

'A lot of human diseases are caused by multiple gene mutations that are difficult to identify,' said Boeke, who is a professor of molecular biology and genetics and director of the High Throughput Biology Center at the Hopkins School of Medicine."

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