Friday, September 01, 2006
In an update to an entry made on Tuesday, August 08, 2006 (appended below) a short video featuring Mario Capecchi commenting on his work is now available at this page.
Scientists Reverse Evolution, Reconstruct Ancient Gene: University of Utah scientists have shown how evolution works by reversing the process, reconstructing a 530-million-year-old gene by combining key portions of two modern mouse genes that descended from the archaic gene.
"It provides further evidence at the molecular level of how evolution has occurred and is occurring, and thus makes the process less mysterious," says Mario Capecchi, distinguished professor and co-chairman of human genetics at the University of Utah School of Medicine and an investigator with the Howard Hughes Medical Institute.
"We've shown some of the elements involved in the process of evolution by reversing this process and reconstructing a gene that later became two genes," he adds.
The study by Capecchi and postdoctoral fellow Petr Tvrdik was set for publication Monday, Aug. 7 in the August 2006 issue of the journal Developmental Cell (Abstract).